Ibutamoren (MK-677) is a potent, long-acting, selective androgen receptor modulator (SARM), and acts as a growth hormone secretagogue, mimicking the growth hormone (GH)-stimulating action of the endogenous hormone ghrelin in eukaryotes. It has been shown to increase the secretion of several hormones including GH (growth hormone) and insulin-like growth factor 1 (IGF-1) and produces sustained increases in the plasma levels of these hormones without affecting cortisol levels in rat models. Studies have shown MK-677 to act as a potent growth hormone secretagogue, meaning it stimulates the release of GH from the pituitary gland. Growth hormone plays a crucial role in various physiological processes such as muscle growth, tissue repair. Not intended for human consumption. These statements have not been evaluated by the FDA and this research compound is in no way intended to treat, diagnose or prevent any disease or condition. Research use only. Not for human consumption.
Compound CID: 178024
MF: C27H36N4O5S
MW: 528.7g/mol
References:
1.) PubChem. "PubChem." Pubchem.ncbi.nlm.nih.gov, pubchem.ncbi.nlm.nih.gov/#query=mk677. Accessed 12 May 2024.
2.) Northrup, R., et al. "Effect of Ghrelin and Anamorelin (ONO-7643), a Selective Ghrelin Receptor Agonist, on Tumor Growth in a Lung Cancer Mouse Xenograft Model." Supportive Care in Cancer, vol. 21, no. 9, 12 Apr. 2013, pp. 2409–2415, https://doi.org/10.1007/s00520-013-1800-0. Accessed 23 Oct. 2022.
3.) Ankersen, Michael, et al. "A New Series of Highly Potent Growth Hormone-Releasing Peptides Derived from Ipamorelin." Journal of Chemistry, vol. 41, no. 19, Sept. 1998, pp. 3699–3704, https://doi.org/10.1021/jm9801962.
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