HOW WILL CBD MAKE ME FEEL? The impact CBD has on the human body is, given the way we are mostly all made the same inside, similar for many people. However, the dosage you take, the strain of hemp used in the product, how/where the product is grown, extraction and other ingredients included, not to mention the reason you have chosen to take CBD products in the first place, all make for unique experiences. As a very simple explanation, you can think of the core effect of CBD as being similar to that you experience when you take something like Paracetamol (Acetaminophen). When it takes effect you experience the absence of symptoms and a return back to a more 'normal' state - more 'you'. First and foremost, legal, professionally made CBD products in the UK will not get you high. There's little to no THC present in CBD oil that is sold legally in this country - that's the psychotropic compound commonly associated with the heady, almost drunk feeling you can get from consuming marijuana. However, that being said, stronger doses of CBD (1,000mg+, far more than would ever normally be consumed) may make you feel ever-so-slightly light headed, briefly, as it works its way into your bloodstream and around the receptors in your body. This is nothing to be concerned about. In fact, this sensation is mostly your own 'bliss molecule', the endocannabinoid called Anandamide, being allowed to flow freely as a result of CBD binding to your CB1 and CB2 receptors which then changes the shape, blocking Anandamide's usual spot, while inhibiting the enzyme which would ordinarily break Anandamide down before it has a chance to get around. If THC is also present, this sits tightly in those receptors so there's no chance of Anandamide settling in, making for even more of that lovely stuff swimming around your system. But this little 'rush' isn't the case for everyone. In fact, those with acute pain, anxiety, sleep deprivation (to name but a few) often find that all they feel is a sudden sense of equilibrium, perhaps manifested as pain reduction, a wash of soothing calm, or an energy boost. Interestingly, the same goes for many people using medical marijuana for acute distress, even with higher levels of THC present. Many experts have theorised that this feeling of restored balance may come from a regulation of something dubbed an 'endocannabinoid deficiency' – an extremely common problem where our bodies have stopped producing and delivering appropriate amounts of Anandamide and a wide variety of other endocannabinoids, resulting in troubles with many cognitive and physiological processes, such as memory, pain, stress response, and appetite. A number of factors are thought to cause endocannabinoid deficiency, such as lack of quality sleep, poor diet and chronic stress. CBD products simply help your body return to centre. HOW CAN I START USING CBD IN THE MOST EFFECTIVE WAY? CBD oral drops The best way to consumer CBD is often a personal choice. The most common way is to start with CBD oil drops, taken under the tongue. Simply place 4-5 drops under your tongue and allow to absorb for 90 seconds before swallowing. It's really important to seek out high a quality product, from a reputable brand where you can be assured that you're getting what's on the label. Ideally a broad spectrum CBD oil, rather than one based on CBD isolate, so that you also get the benefit of the other minor cannabinoids and terpenes present in the cannabis plant (hemp plant). Beware brands trying to pass off Hemp Oil as CBD Oil - they are not the same thing! You can read about the Difference between Hemp Oil and CBD Oil here. KLORIS CBD are one of the most awarded CBD brands, with stringent quality control and are available for next-day delivery from this website, found in leading health spas like Six Senses and Bvlgari and are one of the only CBD oil brands to be recognised under the Medical Cannabis Clinicians Society Criteria For Excellence. HOW CAN CBD AFFECT PEOPLE IN SO MANY DIFFERENT WAYS? Does it seem a little strange to you that some people use CBD to relax while others use it as a pick-me-up? It's certainly a very special property of CBD products and it comes down to two things: Cannabis is pleiotropic, meaning it has many different effects through many molecular pathways and activates or binds to multiple receptors throughout the body. Cannabis, although not officially labelled as an adaptogen, contains cannabinoids which work in a typically adaptogenic way, adapting their function depending on what the body needs, be that physical, chemical or biological. Cannabis (and adaptogens such as Ginseng and Reishi mushroom), bring the body back into balance, moderating stress response, lowering inflammation and even enhancing mental performance. What's more, they can possess opposing qualities, such as being stimulating and relaxing at the same time. Whatever your body needs when the adaptogen gets involved. Amazing, huh? DOES CBD REALLY RELIEVE PAIN? CBD for pain relief Cannabinoids on their own are endlessly captivating – there's so much we have learned already, yet there is still so much more to discover. But one thing we do know is that it's how these cannabinoids work in synergy with each other (the entourage effect) and with the endocannabinoid system (ECS) that gives the results people are raving about. Really, they're just a gentle helping hand to encourage your own body to function just as it should. The ECS spans the entire body. It's considered to be one of the most important and complex networks, alongside the Central Nervous System (CNS) and Immune System. The receptors that make up the ECS have even been found within the CNS and Immune System and are now known to regulate mood, pain, inflammation, appetite, coordination among many, many other functions./p> Because of this, plenty of CBD users have claimed that they find CBD to be extremely effective when it comes to pain relief, when taken internally, as transdermal patches and also when applied topically, as receptors are also found in almost every skin cell throughout all lipid layers. It's not possible to make any hard claims as to this yet though. IS CBD OIL ADDICTIVE? You may find that once you start taking CBD oil, the change to your body is so wonderful that you'll not want to be without it! But this isn't because it's addictive. It's just a game-changer. At a molecular level CBD is not in any way addictive and numerous studies have shown this to be the case. In contrast, evidence suggests that CBD may actually help combat existing addiction to substances such as tobacco, alcohol and even opioids. One week-long 2013 study published in the Addictive Behaviours journal found that participants given a CBD inhaler to use every time they felt the need to smoke reduced their number of cigarettes by 40%, while those with the placebo showed no notable difference. Another 2019 study published in the American Journal of Psychiatry observed the effects of treating long-term heroin users with CBD. The 42 subjects were split into three groups, one had 400mg of CBD administered, the second were given 800mg and the third received a placebo. The results showed that those who used CBD experienced significantly less cravings and anxiety induced by the drug cues. CAN I DRINK ALCOHOL WHILE TAKING CBD? Mixing cannabis with alcohol is usually a no-no, as many a teenager will attest to, however, this is not the case when it comes to low THC or THC free CBD products. Where marijuana with booze might leave you feeling very much worse for wear, CBD is actually thought to have the opposite effect by soothing alcohol induced depression and anxiety for a far more relaxed buzz. Better still, the negative side effects of drinking could be somewhat cushioned by including CBD in your tipple. One 2013 study in the journal of Pharmacology Biochemistry and Behaviour, found that CBD reduces the neurodegeneration drinking can cause, while another 2014 study published in the journal of Free Radical Biology and Medicine revealed that CBD protects the liver by inhibiting oxidative stress and increasing the destruction of damaged cells. This, blended with everything else CBD helps your body do, could not only make for a more enjoyable night, but a more bearable morning after too. CAN I TAKE CBD WITH MEDICATION? There is still so much to learn about CBD and this is one area that is crying out for attention - the reason for this being that the potential CBD has for those on medication could possibly be great, or not good at all. Cannabidiol (and cannabis, including THC and all other cannabinoids) has a fantastic safety record as a food supplement, even in high doses. Unlike many pharmaceutical medications there's no chance of serious harm if you take a little more than you mean to. However, some studies have indicated that CBD has the ability to block a family of enzymes called cytochrome P450, which are responsible for metabolising (and therefore eliminating) 70% to 80% of pharmaceutical drugs in the liver. If enough research is done and safety measures are put into place, this could open up the possibility of patients being able to take much lower doses of their medication when used alongside CBD oil. But it could also indicate build up of pharmaceutical chemicals in your system, which may end being very toxic. Until we know more, it's best to err on the side of caution. And of course, always consult a medical professional for their expert advice. DOES CBD OIL HAVE ANY NEGATIVE SIDE EFFECTS? A huge and ever-increasing number of studies looking into cannabidiol are now (thankfully and finally!) being published on a yearly basis, and the vast majority of them are pointing towards CBD being a pretty amazing thing in almost all respects. But as this is still a relatively new science (the ECS was only discovered in the 90s after all) and widespread use of concentrated CBD is a recent thing, we are always learning. So far, the World Health Organisation deems CBD as perfectly safe, without risk of dependency or abuse and full of promise for a wide range of medical uses. The only clinical trial showing negative side effects has been through using extremely high doses of Epidiolex, an FDA-approved CBD prescription medication. This looked at daily doses equivalent to 1,360 mg (more than an entire bottle of most CBD products) and even that exhibited mild symptoms such as dry mouth, decreased appetite and gastrointestinal distress. That being said, it is vitally important to be wary of poor quality, unregulated CBD products. When purchasing CBD, always look for organic growing methods and transparent lab reports to ensure you are only ever putting the very best ingredients into your body. HOW LONG WILL I FEEL THE EFFECT OF CBD FOR? You're probably wondering how long does CBD last - this mostly depends on what form of CBD you take (i.e. oil, capsules, vapes, edibles etc). Vaping or using cbd oil drops sublingually (under the tongue) ensures the CBD enters your bloodstream fast, and you'll start to feel the effects within 5-10 minutes. Capsules and edibles take much longer to get to work (up to 90 minutes) and, due to having to go via your digestive system, will end up having lower bioavailability too (so you need to take much more to have the same effect). But they're great for a slow, steady, accumulative build up. Once CBD is in your system, however it gets there, it will reach what's known as 'elimination half-life' (the time it takes to reach half the dosage in your body) in 18 to 32 hours. But you won't feel it as strongly during this whole time as you do when it first gets going (what's called 'active life'), even though those lovely cannabinoids will still be subtly working away. HOW CAN I MAKE SURE I GET THE BEST CBD? Knowing which are the best CBD products to try can be a confusing task, but there are a few easy things to check: Make sure the source of the CBD is clearly labelled as hemp, or Cannabis Sativa L. This form of the cannabis plant is naturally low in THC and is the only legal source of CBD for non-medicinal products in the UK and Europe. Ingestible products like CBD oil should ideally be made from broad spectrum CBD extract, meaning that there are other minor compounds present, as naturally found in the hemp plant. There is growing evidence to suggest this more natural form is more beneficial than 'purified' CBD isolate. Ensure that there are current laboratory analysis reports (sometimes called Certificates of Analysis, or COAs) available for your products. These should show the levels of CBD, THC and other cannabinoids. If the certificates don't show the company name and a batch number that matches your product, or are more than a year old, be wary. Organic is always better. Hemp plants are very good at sucking up toxins from the soil. Look for well known third party accreditations, reviews and awards that show the brand is legitimate. | | Cannabidiol (CBD) is an oil derived from the cannabis plant. Possible health benefits include reducing inflammation and pain. However, it is not legal in all states, and there may also be some risks. In June 2018, the Food and Drug Administration (FDA)Trusted Source approved the prescription use of Epidiolex, a purified form of CBD oil, for treating two types of epilepsy. Other forms of cannabis are legal in other states. Cannabis contains a wide range of compounds, with varying effects. Some — but not all— are useful as a treatment. Similarly, some forms — but not all — are legal in some states. This article will look at what CBD is, how it might benefit a person's health, how to use it, any possible risks, and its legal status in the United States. Is CBD legal?The 2018 Farm Bill removed hemp from the legal definition of marijuana in the Controlled Substances Act. This made some hemp-derived CBD products with less than 0.3 percent THC federally legal. However, CBD products containing more than 0.3 percent THC still fall under the legal definition of marijuana, making them federally illegal but legal under some state laws. Be sure to check state laws, especially when traveling. Also, keep in mind that the FDA has not approved nonprescription CBD products, and some products may be inaccurately labeled. ADVERTISEMENT What is CBD oil? CBD oil may help manage symptoms of chronic pain. CBD is one of many cannabinoids (compounds) in the cannabis plant. Researchers have been looking at the possible therapeutic uses of CBD. Two of the compounds in marijuana are delta-9 tetrahydrocannabinol (THC) and CBD. These compounds have different effects. Until recently, THC was the best-known compound in cannabis. It is the most active constituent, and it has a psychological effect. It creates a mind-altering "high" when a person smokes it or uses it in cooking. This is because THC breaks down when a person applies heat and introduces it into the body. CBD, in contrast, is not psychoactive. It does not change a person's state of mind when they use it. However, it may produce significant changes in the body, and it is showing some significant medical benefits. Find out more about the differences between CBD and THC. Where does CBD come from? CBD comes from the cannabis plant. People refer to cannabis plants as either hemp or marijuana, depending on how much THC they contain. The FDA note that hemp plants are legal under the Farm Bill, as long as they contain less than 0.3%Trusted Source THC. Over the years, marijuana farmers have selectively bred their plants to contain high levels of THC and other compounds that suited their interests. However, hemp farmers rarely modify the plant. CBD oil comes from these legal hemp plants. How CBD works All cannabinoids produce effects in the body by interacting with cannabinoid receptors, which form part of the endocannabinoid systemTrusted Source. The body produces two receptors: CB1 receptors are present throughout the body, particularly in the brain. They co-ordinate movement, pain, emotion, mood, thinking, appetite, memories, and other functions. CB2 receptors are more common in the immune system. They affect inflammation and pain. THC attaches to CB1 receptors but CBD stimulatesTrusted Source the receptors so that the body produces its own cannabinoids, known as endocannabinoids. For more information and resources on CBD and CBD products, please visit our dedicated hub. Benefits CBD may benefit a person's health in various ways. According to a 2018 studyTrusted Source, reasons for taking CBD oil include: chronic pain arthritis or joint pain anxiety and depression sleep disorder migraine cluster and other headaches post-traumatic stress disorder (PTSD) nausea cancer allergies or asthma epilepsy and other seizure disorders multiple sclerosis (MS) lung conditions Parkinson's disease Alzheimer's disease There is some evidence to support some of these uses. How does CBD help relieve pain? Learn more here. Natural pain relief and anti-inflammatory properties Conventional drugs can help relieve stiffness and pain, but some people see CBD as a more natural alternative. There is growing evidenceTrusted Source that the non-psychoactive compounds in marijuana, such as CBD, could provide a new treatment for chronic pain. In 2018, mouse studies showed that CBD reduces inflammation by preventing the release of compounds that trigger inflammation in the body. A 2019 study showed that CBD applied to the skin as an ointment significantly reduced inflammatory skin disease and scarring. Quitting smoking and drug withdrawal A 2013 pilot studyTrusted Source found that smokers who used inhalers containing CBD smoked fewer cigarettes than usual and stopped craving nicotine. This suggests that CBD may help people quit smoking. A 2018Trusted Source study found that CBD helped reduce cravings during withdrawal from tobacco because of its relaxing effect. Authors of a 2015 reviewTrusted Source found evidence that specific cannabinoids, such as CBD, may help people with opioid addiction disorders. The researchers noted that CBD reduced some symptoms associated with substance use disorders. These included anxiety, mood-related symptoms, pain, and insomnia. Research continues to support CBD's use in managing withdrawal symptoms. Epilepsy After years of research into the safety and effectiveness of CBD oil for treating epilepsy, the FDATrusted Source approved the use of Epidiolex, a purified form of CBD, in 2018. They approved it for treating the following in people aged 3 years and over: Lennox-Gastaut syndrome Dravet syndrome These rare forms of epilepsy involve seizures that are difficult to control with other types of medication. ScientistsTrusted Source are beginning to understand how CBD prevents seizures without the sedating side effects of medications used previously. Synthetic drugs are not yet available that target the endocannnabinoid system as CBD does. Learn more here about Epidiolex (cannabidiol). Alzheimer's disease Numerous studies have looked at the effect of CBD on Alzheimer's disease. In 2014, a rodent studyTrusted Source showed that CBD might help people retain the ability to recognize familiar faces. People with Alzheimer's can lose this ability. One 2019 review found that CBD might help slow the onset and progress of Alzheimer's disease. More research is underway to understand the dosage better. Some scientistsTrusted Source believe a treatment involving both THC and CHD may be more effective. Other neurological symptoms and disorders Research suggests that CBD may also help treat complications linked to epilepsy, such as neurodegeneration, neuronal injury, and psychiatric diseases. A 2012 studyTrusted Source found that CBD may produce effects similar to those of certain antipsychotic drugs and that the compound may provide a safe and effective treatment for people with schizophrenia. However, further research is necessary. Fighting cancer Authors of a 2012Trusted Source review found evidence that CBD may help prevent the spread of some types of cancer. The compound appears to suppress the growth of cancer cells and promote their destruction. The researchers pointed out that CBD has low levels of toxicity. They called for more research into how CBD could support standard cancer treatments. A 2020 review article discusses adding CBD to chemotherapy drugs to improve the immune system's response to cancer treatment. Other research has been looking at how CBD might help: prevent the growth of cancer cells reduce anxiety improve the action of chemotherapy lessen the side effects of conventional chemotherapy Learn more here about CBD and cancer. Anxiety disorders Doctors have often advised people with chronic anxiety to avoid cannabis, as THC can trigger or amplify feelings of anxiousness and paranoia. CBD, on the other hand, may help reduce anxiety. A 2019 study showed that CBD significantly reduced symptoms in mice with anxiety. Authors of a 2015 reviewTrusted Source had previously suggested that CBD might help reduce anxiety-related behaviors in people with the following conditions: PTSD general anxiety disorder (GAD) panic disorder social anxiety disorder obsessive-compulsive disorder The authors noted that current treatments could have adverse effects, and some people stop using them for this reason. However, there is no evidence to confirm that CBD has significant adverse effects. Type 1 diabetes Type 1 diabetes occurs when the immune system attacks cells in the pancreas, leading to inflammation. In 2016, researchers found evidence that CBD may ease this inflammation and protect against or delay the onset of type 1 diabetes. In a 2018 study, CBD appeared to have neuroprotective effects on rats with diabetes, including helping preserve their memory and reducing nerve inflammation. Acne Acne treatment is another promising use for CBD. The condition is caused, in part, by inflammation and overworked sebaceous glands in the body. A 2014 studyTrusted Source found that CBD helps to lower the production of sebum that leads to acne, partly because of its anti-inflammatory effect. Applying CBD topically may reduce inflammation in psoriasis and other inflammatory skin diseases, according to research. CBD is becoming a more common ingredient in skin creams and ointments. However, some experts have concerns about the lack of evidence regarding its effectiveness and the lack of regulation. ADVERTISEMENT Legality The legal status of CBD in the U.S. is complex. Hemp and hemp-derived products are legal under the Farm Bill, as long as their THC content is less than 0.3%.Trusted Source However, there is still some confusion over the specifics. People should check the laws in their state and any travel destination. It is worth remembering that the FDATrusted Source have not yet approved any nonprescription products, which means people cannot be sure about what their product contains. Risks and side effects As with most therapies, CBD use may entail some risks. It may interact with supplements and other drugs. Most CBD products do not have FDA approval, which also means they have not undergone thorough tests. It is not possibleTrusted Source to know if a product: is safe and effective for everyone to use has the properties or contents stated on the packaging Anyone who is using CBD – whether as a prescription drug or in other forms — should first speak to a doctor. Possible adverse effectsTrusted Source include: liver damage interactions with other drugs and alcohol changes in alertness, which can make driving dangerous gastrointestinal problems and loss of appetite mood changes, including irritability and irritation a reduction in fertility for males Future research may prove CBD effective in treating various conditions. For now, however, the FDA urge people not to depend on CBD as an alternative to conventional medical care. During pregnancy ExpertsTrusted Source believe that using marijuana during pregnancy may affect the fetal development of neurons. Regular use among teens is associated with issues concerning memory, behavior, and intelligence. The FDA adviseTrusted Source people not to use CBD during pregnancy or while breastfeeding. How to use CBD There are various ways of using CBD oil. These are not the same as using or smoking whole cannabis. If a doctor prescribes CBD for epilepsy, it is important to follow their instructions. Ways of using CBD products include: mixing them into food or drink taking them with a pipette or dropper swallowing capsules massaging a paste into the skin spraying it under the tongue Recommended dosages vary between individuals and depend on factors such as: body weight the concentration of the product the reason for using CBD Click here to learn more about CBD dosage. Summary There is growing interest in CBD as a therapy for various conditions, but only one product currently has FDA approval. Unapproved products are legal in some, but not all, states. As regulation in the U.S. increases, more specific dosages and prescriptions will start to emerge. For now, people should ask a healthcare professional for advice about which product to use and how much to take. They should also research to ensure they are following regional and local laws. The FDATrusted Source provide information about a wide range of issues relating to CBD use. | | | | |
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