 Practical Investment Analysis for the New Energy EconomyAI Is Rewriting the Rules of Biotech ForeverMore than a century ago, a German physician named Paul Ehrlich tested hundreds of compounds to find a medical treatment for syphilis. As you might expect, it took him years. You know what they say — the 606 time is the charm. That 606th compound became known as Salvarsan, and it delivered Ehrlich a Nobel Prize for his efforts. There was one slight problem with Ehrlich's method. He was essentially blindly throwing darts at a wall in hopes of hitting a bullseye. But hey, that's how things were back in the 20th century. Drug discovery involved synthesizing thousands of molecules, testing them one by one, and praying that you didn't kill any mice. If that sounds a little tedious, that's because it is. Today, AI is re-writing the rules for drug discovery, and I have a feeling that few people realize just how powerful this technology is. After all, most people can only connect AI to simple chatbots. You and I know there are better ways to utilize it. Just think, AI technology screens billions of virtual compounds before lunch. The transformation everyone kept promising is actually happening now, and it's not the usual biotech theater. Trump's Bold Move to Kill the IRS — $21,307 Payouts IncomingTrump just launched a $1 trillion National Fund to replace taxes with direct payouts. Everyday Americans could claim up to $21,307 — but only if they act before the first checks go out. AI Is Rewriting the Rules of Biotech Forever Truth is, the first innings of AI drug discovery are already underway… A few weeks ago, Insilico Medicine published Phase IIa data for a drug treating idiopathic pulmonary fibrosis — the kind that scars your lungs until you can't breathe. And you know what? The drug worked. Patients in the highest dose group didn't just slow their decline — they improved! Now here's what matters: both the target and the molecule were discovered by algorithms. It took just 18 months from hypothesis to human trials. For the record, that development came at a mind-blowing one-tenth of the usual drug development cost. There was no Nobel-winning chemist staring at molecular models for years, just neural networks trained on biological data doing what neural networks do — finding patterns humans miss. To date, more than 200 AI-discovered drugs are in clinical development, and the first FDA approval is expected within the next year and a half… probably soon! Last year, this was a $2 billion market, but we may soon see it swell to more than $16 billion by 2034. That means one of two things — either everyone's buying the hype, or the infrastructure is finally catching up to the promises. The smart money says it's the latter. Look, traditional drug development operates like molecular roulette. As you know, scientists synthesize thousands of compounds, test them methodically, and hope one might work. The process typically spans four to six years before a single promising candidate emerges, consuming hundreds of millions of dollars along the way. What's truly disheartening, however, are the high failure rates — roughly 90% of drugs entering clinical trials never reach patients. That alone makes the economics punishing. The good news is that right now, AI drug platforms are dismantling this model. Insilico Medicine has nominated 22 development candidates since 2021, synthesizing only 60 to 200 molecules per program compared to the thousands required by conventional methods. In fact, their Pharma.AI platform integrates target discovery, molecular design, and clinical outcome prediction into a seamless workflow. To put it another way, this technology achieved what took Paul Ehrlich 606 attempts in a matter of computational cycles. And the mechanics behind this acceleration reveal why AI succeeds where traditional chemistry falters. Machine learning algorithms trained on massive biological datasets can identify disease-relevant protein targets by analyzing patterns across genomics, clinical data, and scientific literature. Once a target emerges, generative AI designs novel molecular structures optimized for specific properties: binding affinity, metabolic stability, reduced toxicity. Physics-based simulations then predict how these compounds will behave in the human body before any lab synthesis occurs. Schrodinger advanced a drug candidate from concept to clinical trials in ten months. Their LiveDesign platform now integrates Eli Lilly's TuneLab AI system, giving biotech companies access to models trained on years of pharmaceutical research data. But the real revelation here is that this democratization of advanced discovery tools means smaller firms can now compete with industry giants. And what's particularly striking is the convergence happening across therapeutic areas. Trump Bet $2 Billion on Bitcoin — But This 30-Cent Stock May Beat Him While Trump Media pours billions into Bitcoin, a 30-cent stock is fueling something even bigger: NatGold — the next evolution of digital gold. It's backed by real, verified in-ground gold... digitally "mined" with zero environmental impact. And this tiny firm controls 73% of the supply. Click here to see why NatGold is the future of money — and how to get in early. The New Age of AI Discovery The transformation of drug discovery from art to science creates compelling opportunities for investors who understand what's actually changing. This isn't about picking individual drug candidates — clinical trial outcomes remain inherently uncertain. Rather, the shift happening now is structural: Companies with validated AI platforms are building sustainable competitive advantages that compound over time. Consider the economics here for a moment… Traditional pharmaceutical companies spend $2.6 billion on average to bring one drug to market, with most of that cost absorbed by failed attempts. AI-driven discovery collapses both timelines and costs while improving success rates. So far, early data suggests AI-discovered drugs achieve Phase I success rates near 80-90%, or roughly double the industry norms. As these platforms mature and accumulate more proprietary data, their predictive accuracy strengthens — creating a flywheel effect that becomes increasingly difficult for competitors to replicate. For us, the key is being able to distinguish genuine technological capability from marketing narratives. Look for companies demonstrating clinical validation: molecules actually advancing through trials, not just computational predictions. Partnerships with major pharmaceutical firms signal credible platforms. Financial runway matters — drug development takes years, and companies need resources to see programs through inflection points. And make no mistake, the broader sector dynamics favor early movers. As AI platforms accumulate proprietary biological data, they build moats that new entrants struggle to overcome. This moment in biotech history parallels other platform shifts that created enormous value for early investors. When monoclonal antibodies emerged in the 1990s, or when precision oncology gained traction in the 2010s, those who recognized the structural change early captured substantial returns. AI drug discovery represents a similar inflection, with the added dimension that it applies across therapeutic areas rather than just one modality. This isn't merely an incremental improvement — we're staring at a legitimate game-changer for AI to finally deliver on biotech's long-standing promise of making medicine more predictive, personalized, and accessible. And you can bet the biotech players cracking this code aren't just building better pipelines. They're the hidden investment gems establishing AI-driven drug platforms that could discover hundreds of drugs over the coming decades. Go ahead and take a look at one biotech stock that's already ahead of the pack. Until next time,
Keith Kohl P.S. This New Fuel Is Making Nuclear Obsolete A stunning new breakthrough is unleashing a fuel rated at 50,000 zettajoules — enough energy to dwarf oil, gas, coal, solar, and nuclear combined. It's limitless, it's everywhere, and, according to the U.S. Department of Energy, it could power the world for billions of years… at zero cost. This quiet revolution is already underway — and the profit potential tied to the companies harvesting it is almost impossible to quantify.
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